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Oral contraceptives reduce general well-being in healthy women


One of the most typical mixed oral contraceptive tablets has a unfavourable influence on women’s high quality of life however doesn’t improve depressive signs. This is proven by a serious randomised, placebo-controlled research carried out by researchers at Karolinska Institutet in Sweden in collaboration with the Stockholm School of Economics. The outcomes have been revealed in the scientific journal Fertility and Sterility.


“Despite the truth that an estimated 100 million women around the globe use contraceptive tablets we all know surprisingly little right now concerning the capsule’s impact on women’s health. The scientific base could be very restricted as regards the contraceptive capsule’s impact on high quality of life and depression and there’s a nice want for randomised research the place it’s in contrast with placebos,” says professor Angelica Lindén Hirschberg on the Department of Women’s and Children’s Health at Karolinska Institutet.


She has led simply such a research along with Niklas Zethraeus, affiliate professor on the Department of Learning, Informatics, Management and Ethics, Anna Dreber Almenberg from the Stockholm School of Economics, and Eva Ranehill of the University of Zürich. 340 healthy women aged between 18 and 35 have been handled randomly over the course of three months with both drugs with no impact (placebos) or contraceptive drugs containing ethinylestradiol and levonorgestrel, the most typical type of mixed contraceptive capsule in Sweden and lots of different nations. Neither the leaders of the experiment nor the themes knew which remedy was given to which women.


The women who got contraceptive tablets estimated their high quality of life to be considerably decrease than those that got placebos. Both general high quality of life and particular points like temper/well-being, self-control and power degree have been affected negatively by the contraceptives. On the opposite hand, no vital improve in depressive signs was noticed.


Since the modifications have been comparatively small, the outcomes have to be interpreted with a specific amount of warning, the researchers emphasise. In the case of particular person women, nevertheless, the destructive impact on high quality of life could also be of medical significance.


“This may in some instances be a contributing reason for low compliance and irregular use of contraceptive drugs. This potential degradation of high quality of life ought to be paid consideration to and brought under consideration in conjunction with prescribing of contraceptive tablets and when selecting a way of contraception,” says Niklas Zethraeus.


The sort of mixed contraceptive capsule that was used in the research (etinylestradiol + levonorgestrel) is advisable in many nations as the primary selection since it’s thought-about to ivolve the least danger of thrombosis among the many mixed contraceptive tablets. The findings from the research can’t be generalised to other forms of mixed contraceptive tablets as a result of they could have a unique danger profile and side-effects.


The research was supported by analysis grants from Jan Wallander and Tom Hedelius Foundation, Knut and Alice Wallenberg Foundation, Swedish Council for Working Life and Social Research, the Swiss National Science Foundation, the Swedish Research Council, Karolinska Institutet, and the regional settlement on medical coaching and medical analysis (ALF) between Stockholm County Council and Karolinska Institutet.


Article: A primary selection mixed oral contraceptive influences general well-being in healthy women – a double-blind, randomized, placebo-controlled trial, Niklas Zethraeus, Anna Dreber, Eva Ranehill, Liselott Blomberg, Fernand Labrie, Bo von Schoultz, Magnus Johannesson, Angelica Lindén Hirschberg, Fertility and Sterility, doi:10.1016/j.fertnstert.2017.02.120, revealed on-line 18 April 2017.


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