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OnMedica – News – Early menopause linked to heart failure risk


Women who had shorter complete reproductive period or by no means gave start at greater risk

Louise Prime

Tuesday, 16 May 2017


Women who went by way of menopause early or who’ve by no means given delivery could also be at larger risk of being hospitalised with heart failure than different women, US analysis has discovered.

The authors of the study* revealed within the Journal of the American College of Cardiology stated infertility didn’t clarify the affiliation and referred to as for extra analysis into mechanisms behind the potential cardioprotective impact of reproductive hormones in women.

The authors added that earlier analysis had discovered that a lady’s risk of heart illness is perhaps influenced by hormones current in the course of the reproductive interval, suggesting that women who expertise early menopause is perhaps at an elevated risk for heart illness.

The researchers, who have been led from the San Francisco School of Medicine, additionally identified that hormone ranges through the reproductive interval is perhaps affected by menstrual biking and being pregnant.  

They analysed knowledge from the Women’s Health Initiative, together with 28,516 postmenopausal women (imply age at baseline 62.7 years) with out heart problems, to determine associations between the women’s risk of incident heart failure and complete variety of reside births, age at first being pregnant lasting no less than six months, and complete reproductive period (time from first menstruation to menopause).

They reported that in a imply 13.1 years’ comply with up, 5.2% of those women have been hospitalised for heart failure. Short complete reproductive period was related to an elevated risk of heart failure, which was additionally extra pronounced in women who skilled pure, relatively than surgical, menopause.

The researchers additionally discovered that women who had by no means given delivery have been at an elevated risk for diastolic heart failure and that having extra youngsters was not related to heart failure risk.

The research authors concluded: ‘In publish-menopausal women, shorter complete reproductive period was related to larger risk of incident HF, and nulliparity was related to greater risk for incident HF with preserved ejection fraction. Whether publicity to endogenous intercourse hormones underlies this relationship ought to be investigated in future research.’

The writer of an accompanying editorial** wrote that though the mechanisms of those findings are unclear, their significance and potential influence on women’s health is actual. She added: ‘There additionally stay many unresolved questions together with the mechanisms of oestrogen’s cardioprotective impact, making this really a piece in progress. Altogether, these findings increase fascinating questions concerning the cardiometabolic results of intercourse hormone publicity over a lady’s lifetime and proceed to increase necessary questions for future analysis.’


* Hall PS, Nah G, Howard BV, et al. Reproductive elements and incidence of heart failure hospitalization within the women’s health initiative. Journal of the American College of Cardiology 2017; 69 (20): doi:10.1016/j.jacc.2017.03.557

** Scott NS. Understanding hormones, menopause, and heart failure. Journal of the American College of Cardiology 2017; 69 (20) doi: 10.1016/j.jacc.2017.03.561


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