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Higher levels of biomarker linked to increased stroke risk for women

Women with elevated levels of a protein of their blood could also be at a better risk of ischemic stroke, in accordance to a research revealed within the on-line concern of Neurology®, the medical journal of the American Academy of Neurology. The new analysis is available in time for Stroke Awareness Month in May.

The research discovered that an elevated degree of beta-2 microglobulin, a protein discovered on the floor of many cells, was linked to an increased risk of ischemic stroke amongst women. The commonest sort of stroke, ischemic stroke happens when the blood provide to the mind is blocked. The protein can also be a marker for inflammation.

“Recent research have discovered associations between beta-2 microglobulin and heart disease,” stated research writer Pamela Rist, ScD, of Brigham and Women’s Hospital and Harvard Medical School in Boston and a member of the American Academy of Neurology. “However, less is known about the association between beta-2 microglobulin and ischemic stroke.”

Researchers checked out women with a mean age of 61 enrolled within the Nurses’ Health Study who offered blood samples between 1989 and 1990 and who had no historical past of stroke or cancer. Participants have been requested to full questionnaires about their way of life and medical historical past each two years.

To study extra about beta-2 microglobulin and any attainable hyperlink to stroke, researchers measured the protein levels in 473 research members who later had an ischemic stroke in addition to 473 individuals of the identical age who didn’t have a stroke. They have been additionally matched based mostly on different elements that would have an effect on stroke risk, similar to whether or not they smoked or used hormone remedies. The strokes occurred a mean of 9 years after the beginning of the research.

Researchers discovered that members who later had an ischemic stroke had larger levels of beta-2 microglobulin than those that didn’t have a stroke. The common degree of the protein was 1.86 milligrams per liter in those that had ischemic strokes, in contrast to 1.80 mg/L in those that didn’t have a stroke.

The researchers divided the individuals into 4 teams based mostly on their levels of the protein. Those within the highest quarter of beta-2 microglobulin levels have been 56 % extra doubtless to have a stroke than these within the backside quarter. In the highest quarter, 163 of the 283 women had strokes, in contrast to 106 of the 227 women within the backside quarter.

The outcomes have been adjusted for different elements that would have an effect on stroke risk, reminiscent of bodily exercise, high blood pressure and diabetes.

Rist stated that limitations of the research are that it was carried out primarily amongst white women and that it couldn’t look at any modifications in protein levels.

“Given the high rate of disability from stroke, it is important to identify people who may be at higher risk of this disease. This protein could be a marker that might help us in the fight against stroke,” stated Rist. “Further studies are needed to determine if beta-2 microglobulin levels can be modified through lifestyle changes.”

Article: Prospective association between β2-microglobulin levels and ischemic stroke risk among women, Pamela M. Rist, ScD, Monik C. Jiménez, ScD and Kathryn M. Rexrode, MD, MPH, Neurology, doi: 10.1212/WNL.0000000000004006, revealed on-line 10 May 2017.


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